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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
10.3
Human Site:
S614
Identified Species:
18.89
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S614
P
T
R
L
R
E
A
S
K
S
R
V
Q
L
F
Chimpanzee
Pan troglodytes
XP_514624
382
43769
N373
V
P
G
L
K
F
G
N
N
H
L
T
I
W
N
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S716
P
T
R
L
R
E
A
S
K
S
R
L
Q
L
F
Dog
Lupus familis
XP_542986
665
76981
S653
P
D
H
F
R
E
R
S
K
F
K
L
R
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
Q616
N
K
T
S
S
C
L
Q
E
V
S
K
V
K
T
Rat
Rattus norvegicus
XP_230789
677
77635
E666
K
K
T
S
S
C
I
E
E
V
S
K
V
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
E597
W
N
N
R
S
K
T
E
Y
T
T
A
S
E
P
Frog
Xenopus laevis
Q6INN8
632
72730
E620
N
E
G
K
Q
Q
T
E
L
L
H
K
S
R
V
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Q593
E
E
E
E
K
H
R
Q
N
Q
T
L
P
H
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
S576
D
E
V
S
S
S
C
S
T
A
K
R
R
L
E
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
N585
T
R
T
P
S
E
G
N
R
R
R
K
K
P
K
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
A468
G
I
K
A
Q
V
H
A
T
P
E
K
K
K
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
T464
I
K
A
Q
V
H
A
T
P
E
K
K
K
R
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
6.6
93.3
46.6
N.A.
0
0
N.A.
N.A.
0
0
0
N.A.
N.A.
N.A.
13.3
13.3
P-Site Similarity:
100
20
100
66.6
N.A.
6.6
6.6
N.A.
N.A.
13.3
13.3
13.3
N.A.
N.A.
N.A.
33.3
33.3
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
24
8
0
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
16
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
24
8
8
0
31
0
24
16
8
8
0
0
8
8
% E
% Phe:
0
0
0
8
0
8
0
0
0
8
0
0
0
0
24
% F
% Gly:
8
0
16
0
0
0
16
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
16
8
0
0
8
8
0
0
8
8
% H
% Ile:
8
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% I
% Lys:
8
24
8
8
16
8
0
0
24
0
24
47
24
24
8
% K
% Leu:
0
0
0
24
0
0
8
0
8
8
8
24
0
31
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
8
8
0
0
0
0
16
16
0
0
0
0
0
8
% N
% Pro:
24
8
0
8
0
0
0
0
8
8
0
0
8
8
8
% P
% Gln:
0
0
0
8
16
8
0
16
0
8
0
0
16
0
0
% Q
% Arg:
0
8
16
8
24
0
16
0
8
8
24
8
16
16
16
% R
% Ser:
0
0
0
24
39
8
0
31
0
16
16
0
16
0
0
% S
% Thr:
8
16
24
0
0
0
16
8
16
8
16
8
0
0
16
% T
% Val:
8
0
8
0
8
8
0
0
0
16
0
8
16
0
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _